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The changes in cerebral phosphorus metabolites, intracellular pH, and lactate during 30 min of complete global ischemia and 2 h of reperfusion were monitored by time-shared 1H and 31P in vivo NMR spectroscopy in rats. After the induction of ischemia, intracellular pH decreased from 7.14 +/- 0.01 to 6.32 +/- 0.10, and lactate concentration increased from 1.6 +/- 0.4 to 15.8 +/- 2.5 mumol/g; ATP and phosphocreatine were totally depleted, while inorganic phosphate increased 715 +/- 47%. Within 1 h after blood flow was restored, high-energy phosphates and lactate levels had recovered close to baseline levels. The changes in intracellular pH and lactate levels during ischemia and reperfusion correlated well.
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
January 1995,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
January 1992,
Magnetic resonance imaging,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
May 1988,
Stroke,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
April 1994,
Brain research,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
September 1987,
Therapie,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
November 1989,
Magnetic resonance in medicine,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
November 1987,
The Journal of biological chemistry,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
April 1997,
Nihon Ika Daigaku zasshi,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
January 1986,
The Journal of pharmacology and experimental therapeutics,
L H Chang, and
R Shirane, and
P R Weinstein, and
T L James
August 1985,
Biochemistry,
