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The dynamics of 125IUdR-labeled tumor cell retention in the lungs have been compared with the efficiency of lung colony formation over a wide range of inoculum sizes in normal mice and in mice pretreated with 1000 rads local thoracic irradiation (LTI). These studies indicate that the increase in lung colony yield after LTI cannot be ascribed to improved intravascular trapping or interstitial lodgement of tumor cells. Hypotheses purporting that active specific or nonspecific host defense might be impaired by LTI were reassessed but rejected in favor of the idea that radiation-induced alterations in the physiological mocroenvironment of the lungs improve an intrinsically poor survival capability of intravenously disseminated tumor cells.
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
August 1996,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
September 1979,
The British journal of radiology,
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
January 1986,
Respiration; international review of thoracic diseases,
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
April 1976,
Cancer treatment reports,
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
October 1974,
British journal of cancer,
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
August 1989,
Blood,
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
June 1982,
Arerugi = [Allergy],
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
October 1988,
Sheng li xue bao : [Acta physiologica Sinica],
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
June 1986,
Experimental hematology,
L J Peters, and
K Mason, and
W H McBride, and
Y Z Patt
July 1987,
International journal of radiation oncology, biology, physics,
