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C57Bl mice were treated with thoracic irradiation to doses in the range 12.0 to 18.9 gray. Few deaths were observed in the period 80--160 days after irradiation (an end-point of lung damage used by other investigators) and the median survival times ranged from 200 to 310 days. CBA mice treated under identical conditions predominantly died between 80--160 days and it is therefore concluded that C57Bl mice show unusually prolonged survival following this treatment. Six chemotherapeutic agents were given to C57Bl mice together with thoracic irradiation, in most cases two weeks beforehand. Adriamycin, bleomycin and cyclophosphamide enhanced the mortality of the mice. Most agents had little effect on radiation-induced skin damage.
G G Steel, and
K Adams, and
M J Peckham
December 1983,
Radiation research,
G G Steel, and
K Adams, and
M J Peckham
May 1983,
International journal of radiation oncology, biology, physics,
G G Steel, and
K Adams, and
M J Peckham
August 1982,
The American review of respiratory disease,
G G Steel, and
K Adams, and
M J Peckham
September 1982,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
G G Steel, and
K Adams, and
M J Peckham
April 1988,
Radiation research,
G G Steel, and
K Adams, and
M J Peckham
December 1990,
Hematology/oncology clinics of North America,
G G Steel, and
K Adams, and
M J Peckham
December 1980,
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
G G Steel, and
K Adams, and
M J Peckham
February 1978,
Radiology,
G G Steel, and
K Adams, and
M J Peckham
March 2016,
Brain imaging and behavior,
G G Steel, and
K Adams, and
M J Peckham
July 2002,
Lung cancer (Amsterdam, Netherlands),
