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Increased IgA synthesis probably plays a role in the pathogenesis of IgA nephropathy (IgAN). We investigated whether an increased sensitivity to the effect of various growth factor combinations leads to increased immunoglobulin synthesis by peripheral blood mononuclear cells (PBMC) from IgAN patients, in comparison to healthy controls. Although none of the growth factors studied (pokeweed mitogen [PWM], interleukin [IL]-2, IL-6, transforming growth factor-beta [TGF-beta], and combinations) led to greater IgA synthesis in IgAN patients than in controls, the IgA subclass ratio was shifted in favor of IgA1. In controls, but not in IgAN patients, IL-2 enhanced the production of IgA and IgA1 compared with media alone. This possibly reflects previous in vivo activation by IL-2 in IgAN patients. The suppressive effect of TGF-beta on immunoglobulin synthesis was modestly greater in IgAN patients than in controls. Increased production of IL-2 and perhaps other cytokines by T cells in vivo may be responsible for the elevated IgA immune response in these patients.
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
February 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
October 1991,
Clinical nephrology,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
August 1995,
Clinical nephrology,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
May 1982,
Clinical immunology and immunopathology,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
March 1985,
Clinical nephrology,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
December 1987,
Clinical nephrology,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
August 1991,
Clinical and experimental immunology,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
January 1998,
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
November 1981,
The New England journal of medicine,
A W van den Wall Bake, and
P A Crowley-Nowick, and
R Kulhavy, and
J Hermans, and
S Jackson, and
B A Julian, and
J Mestecky
December 1987,
Seminars in nephrology,
