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This work was undertaken to examine the immunoregulation of T lymphocytes in patients with IgA nephropathy. Fifty patients and thirty-seven control subjects were studied in an infection-free interval. T lymphocyte subpopulations were determined using OKT monoclonal antibodies against helper (OKT4) and suppressor (OKT8) T cell subsets. The proportions of T lymphocyte subpopulations did not differ between patients and controls. Patients with significant renal impairment demonstrated a reduced OKT4/T8 ratio (p less than 0.001) due to an absolute reduction of T helper cells (p less than 0.02) and an increase of T suppressor cells (p less than 0.001). Longitudinal studies performed in 13 patients revealed consistent findings during clinical quiescence. However, synpharyngitic macroscopic haematuria was associated with a rise in T4 positive cells and a simultaneous reduction of T8 positive cells; these changes reverted to pre-infection values when the infection subsided. Functional studies assessing T lymphocyte activities including in vitro immunoglobulin synthesis by cultured peripheral blood mononuclear cells, thymidine uptake by cultured lymphocytes and T lymphocytes activation with expression of interleukin-2 receptors were measured in unstimulated and mitogen stimulated cultures. No significant difference between patients with IgA nephropathy in clinical quiescence and the control subjects was demonstrated. Our results failed to support a shift in the immuno-regulatory T lymphocyte subpopulations during clinical quiescence but a more profound defect in immunoregulation may probably occur during clinical exacerbation.
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
March 1985,
Clinical nephrology,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
January 1991,
Nephron,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
May 1982,
Clinical immunology and immunopathology,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
December 1992,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
January 2004,
Roczniki Akademii Medycznej w Bialymstoku (1995),
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
April 2001,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
December 1987,
Seminars in nephrology,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
January 1988,
International urology and nephrology,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
December 1985,
Orvosi hetilap,
K N Lai, and
F M Lai, and
S H Chui, and
Y M Chan, and
G S Tsao, and
K N Leung, and
C W Lam
January 1998,
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia,
