BIOMAT Database Logo BIOMAT Database Logo

[Metabolic consequences of inflammation in kidney failure]. 2003

F Guebre-Egziabher, and D Fouque
Département de néphrologie, Centre de recherche en nutrition humaine, Hôpital Edouard Herriot, Lyon.

Chronic inflammation is very common in patients on maintenance dialysis. It is associated with an increase of many cytokines (especially: IL-1, IL-6 and TNF alpha). This inflammation leads to hormonal dysregulation (leptin, adiponectin, insulin). Increase in cytokines is associated with a high cardio-vascular morbi-mortality for general population as well as for uremic patients. Many metabolic abnormalities are due to chronic inflammation: protein catabolism, anorexia and many others. Among them, the "metabolic" syndrome includes adiposis, dyslipemia, insulinoresistance and high blood pressure very often present in chronic uremic patients. It is still unknown whether anti-inflammatory treatments would improve inflammation consequences in dialysis.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008659 Metabolic Diseases Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed) Thesaurismosis,Diseases, Metabolic,Disease, Metabolic,Metabolic Disease,Thesaurismoses
D002097 C-Reactive Protein A plasma protein that circulates in increased amounts during inflammation and after tissue damage. C-Reactive Protein measured by more sensitive methods often for coronary heart disease risk assessment is referred to as High Sensitivity C-Reactive Protein (hs-CRP). High Sensitivity C-Reactive Protein,hs-CRP,hsCRP,C Reactive Protein,High Sensitivity C Reactive Protein
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016207 Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. Cytokine

Related Publications

F Guebre-Egziabher, and D Fouque
[Metabolic consequences of kidney normothermic ischemia].
January 1983, Voprosy meditsinskoi khimii,
F Guebre-Egziabher, and D Fouque
[Consequences of early failure in kidney transplant].
January 1980, Minerva nefrologica,
F Guebre-Egziabher, and D Fouque
Metabolic consequences of low-temperature kidney preservation.
December 1976, The Journal of laboratory and clinical medicine,
F Guebre-Egziabher, and D Fouque
Metabolic consequences of exercise-associated autonomic failure.
April 2006, Exercise and sport sciences reviews,
F Guebre-Egziabher, and D Fouque
Chronic renal failure: metabolic and clinical consequences.
August 1982, Hospital practice (Office ed.),
F Guebre-Egziabher, and D Fouque
[Metabolic changes in chronic kidney failure].
July 1978, Bratislavske lekarske listy,
F Guebre-Egziabher, and D Fouque
Kidney allograft inflammation and fibrosis, causes and consequences.
May 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
F Guebre-Egziabher, and D Fouque
Plasma Zonulin and its Association with Kidney Function, Severity of Heart Failure, and Metabolic Inflammation.
December 2016, Clinical laboratory,
F Guebre-Egziabher, and D Fouque
[Vitamin metabolic disorders in chronic kidney failure].
January 1992, Nihon rinsho. Japanese journal of clinical medicine,
F Guebre-Egziabher, and D Fouque
Metabolic consequences of feeding a high-carbohydrate, high-fiber diet to diabetic patients with chronic kidney failure.
August 1988, The American journal of clinical nutrition,
Copied contents to your clipboard!