Biomaterial Database

[Metabolic consequences of kidney normothermic ischemia]. 1983

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Normothermic ischemia of kidney within 1 hr caused critical impairments in metabolic reactions of nephrons. Activities of glucose-6-phosphate and lactate dehydrogenases in erythrocytes may characterize the functional state of kidney tissue in ischemia. Amount of 2,3-glucose diphosphate in erythrocytes correlated with the diuresis level. Kidney tissue ischemia led to alteration in the ratio of young and old erythrocyte populations in circulation. Alterations in activity of glucose-6-phosphate and lactate dehydrogenases in urine occurred due to both an increase in kidney clearance and the impairment of kidney tissue.

UI	MeSH Term	Description	Entries
D007511	Ischemia	A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	Ischemias
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D007770	L-Lactate Dehydrogenase	A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.	Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D009399	Nephrons	The functional units of the kidney, consisting of the glomerulus and the attached tubule.	Nephron
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D004905	Erythrocyte Aging	The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.	Erythrocyte Survival,Aging, Erythrocyte,Survival, Erythrocyte
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005954	Glucosephosphate Dehydrogenase		Glucose-6-Phosphate Dehydrogenase,Dehydrogenase, Glucose-6-Phosphate,Dehydrogenase, Glucosephosphate,Glucose 6 Phosphate Dehydrogenase
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia

Related Publications

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Ischemia-induced Metabolic Patterns Associate With Kidney Function During Normothermic Kidney Perfusion: A Preclinical Study.

July 2024, Annals of surgery,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Cellular and metabolic consequences of chronic ischemia on kidney function.

January 1996, Seminars in nephrology,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Definition of normothermic ischemia limits for kidney and pancreas grafts.

June 1986, The Journal of surgical research,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Metabolic needs of the kidney graft undergoing normothermic machine perfusion.

August 2021, Kidney international,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Pathophysiological concepts of ischemia-reperfusion injury and normothermic, ex vivo kidney perfusion.

February 2024, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Normothermic kidney preservation.

April 2011, Current opinion in organ transplantation,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Metabolic consequences of low-temperature kidney preservation.

December 1976, The Journal of laboratory and clinical medicine,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

[Metabolic consequences of inflammation in kidney failure].

January 2003, Nephrologie,

V I Shepotinovskiĭ, and Z I Makashinovich, and G A Kopeliovich

Pure cortical ischemia versus striatal ischemia. Circulatory, metabolic, and neuropathologic consequences.

July 1985, Surgical neurology,