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Pathogen inactivation of platelet concentrates and fresh frozen plasma. 2003

J E Jackson
Department of Transfusion Medicine, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK. jane.jackson@uhl-tr.nhs.uk

Transfusion of blood products carries the risk of pathogen transmission, despite careful donor selection and screening tests. This is due to viral transmission from window-period donations, the emergence of new pathogens such as variant Creutzfeldt-Jakob disease, for which routine screening tests are not yet available, and to bacterial contamination. Techniques have been developed to inactivate pathogens in both fresh frozen plasma and platelet concentrates. The relative benefits to the recipient, and the ease of incorporation into blood component processing are considered for the technologies currently available.

UI MeSH Term Description Entries
D010949 Plasma The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION. Blood Plasma,Fresh Frozen Plasma,Blood Plasmas,Fresh Frozen Plasmas,Frozen Plasma, Fresh,Frozen Plasmas, Fresh,Plasma, Blood,Plasma, Fresh Frozen,Plasmas,Plasmas, Blood,Plasmas, Fresh Frozen
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013242 Sterilization The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
D017713 Platelet Transfusion The transfer of blood platelets from a donor to a recipient or reinfusion to the donor. Blood Platelet Transfusion,Blood Platelet Transfusions,Platelet Transfusion, Blood,Platelet Transfusions,Platelet Transfusions, Blood,Transfusion, Blood Platelet,Transfusion, Platelet,Transfusions, Blood Platelet,Transfusions, Platelet
D017848 Blood-Borne Pathogens Infectious organisms, including pathogenic bacteria, viruses, and fungi, that are present in the BLOOD. Blood-Borne Pathogen,Bloodborne Pathogen,Pathogens, Blood-Borne,Bloodborne Pathogens
D018562 Disease Transmission, Infectious The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). Close-Contact Infectious Disease Transmission,Close-Contact Transmission,Community Spread,Community Transmission,Disease Superspreader Event,Disease Superspreading,Droplet Transmission of Infectious Disease,Droplet Transmission, Infectious Disease,Infectious Disease Droplet Transmission,Person-to-Person Transmission,Autochthonous Transmission,Communicable Disease Transmission,Horizontal Transmission of Infection,Horizontal Transmission of Infectious Disease,Infection Transmission,Infection Transmission, Horizontal,Infectious Disease Transmission,Infectious Disease Transmission, Horizontal,Pathogen Transmission,Pathogen Transmission, Horizontal,Transmission of Infectious Disease,Transmission, Infectious Disease,Autochthonous Transmissions,Close Contact Infectious Disease Transmission,Close Contact Transmission,Close-Contact Transmissions,Community Transmissions,Disease Superspreader Events,Disease Superspreadings,Disease Transmission, Communicable,Event, Disease Superspreader,Events, Disease Superspreader,Infection Horizontal Transmission,Person to Person Transmission,Superspreader Event, Disease,Superspreader Events, Disease,Superspreading, Disease,Superspreadings, Disease,Transmission, Autochthonous,Transmission, Close-Contact,Transmission, Communicable Disease,Transmission, Infection,Transmission, Pathogen,Transmission, Person-to-Person,Transmissions, Autochthonous,Transmissions, Community

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