BIOMAT Database Logo BIOMAT Database Logo

[Pathogen inactivation in platelet concentrates: the French experience]. 2011

J-P Cazenave
Établissement français du sang Alsace, Strasbourg, France. jeanpierre.cazenave@efs-alsace.fr

The transfusion of platelet concentrates is increasing in oncohematology patients due to chemotherapy and hematopoietic stem cell grafts. The transmission of pathogenic agents, viruses, parasites and especially bacteria with platelet concentrates stored at room temperature (20-24°C) is associated with a septic risk, partly prevented by bacterial detection. Photochemical inactivation of platelet concentrates, using a technique associating amotosalen and UVA, has been used for five years in a French region for the whole population and a large spectrum of patients, with efficacy and safety. Universal implementation of pathogen inactivation in labile blood products is a major and key step to improve safety against infection in transfusion.

UI MeSH Term Description Entries
D011564 Furocoumarins Polycyclic compounds consisting of a furan ring fused with coumarin. They commonly occur in PLANTS, especially UMBELLIFERAE and RUTACEAE, as well as PSORALEA. Furanocoumarin,Furanocoumarins,Furocoumarin,Psoralens,Angelicins
D005602 France A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris. Corsica,Saint Pierre and Miquelon,Miquelon and Saint Pierre,Miquelon and St. Pierre,St. Pierre and Miquelon
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014466 Ultraviolet Rays That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants. Actinic Rays,Black Light, Ultraviolet,UV Light,UV Radiation,Ultra-Violet Rays,Ultraviolet Light,Ultraviolet Radiation,Actinic Ray,Light, UV,Light, Ultraviolet,Radiation, UV,Radiation, Ultraviolet,Ray, Actinic,Ray, Ultra-Violet,Ray, Ultraviolet,Ultra Violet Rays,Ultra-Violet Ray,Ultraviolet Black Light,Ultraviolet Black Lights,Ultraviolet Radiations,Ultraviolet Ray
D017053 Infection Control Programs of disease surveillance, generally within health care facilities, designed to investigate, prevent, and control the spread of infections and their causative microorganisms. Control, Infection
D017713 Platelet Transfusion The transfer of blood platelets from a donor to a recipient or reinfusion to the donor. Blood Platelet Transfusion,Blood Platelet Transfusions,Platelet Transfusion, Blood,Platelet Transfusions,Platelet Transfusions, Blood,Transfusion, Blood Platelet,Transfusion, Platelet,Transfusions, Blood Platelet,Transfusions, Platelet
D017848 Blood-Borne Pathogens Infectious organisms, including pathogenic bacteria, viruses, and fungi, that are present in the BLOOD. Blood-Borne Pathogen,Bloodborne Pathogen,Pathogens, Blood-Borne,Bloodborne Pathogens

Related Publications

J-P Cazenave
Pathogen inactivation of platelet concentrates and fresh frozen plasma.
January 2003, British journal of biomedical science,
J-P Cazenave
Economics of pathogen inactivation technology for platelet concentrates in Japan.
November 2004, International journal of hematology,
J-P Cazenave
Bacterial inactivation of platelet concentrates with the THERAFLEX UV-Platelets pathogen inactivation system.
April 2019, Transfusion,
J-P Cazenave
Pathogen inactivation/reduction of platelet concentrates: turning theory into practice.
July 2010, ISBT science series,
J-P Cazenave
Nationwide Implementation of Pathogen Inactivation for All Platelet Concentrates in Switzerland.
May 2018, Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie,
J-P Cazenave
Analysis of reasons for not implementing pathogen inactivation for platelet concentrates.
May 2013, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine,
J-P Cazenave
[The quality of platelet concentrates in dependence on storage time before pathogen inactivation].
March 2011, Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
J-P Cazenave
Methylene blue and thionine in pathogen inactivation of plasma and platelet concentrates.
December 2001, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis,
J-P Cazenave
Viral inactivation in platelet concentrates.
January 1994, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine,
J-P Cazenave
The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates.
November 2014, Blood reviews,
Copied contents to your clipboard!