-transparent.png){kind=logo}
The effects of the new 5HT1A receptor antagonist (S)-UH-301 were investigated in several neurological and behavioral tests in rodents and monkeys. By itself, (S)-UH-301 was found to decrease palatable food consumption in rats, to exhibit anticonvulsant activity in mice, and anxiolytic-like properties in two rodent models of anxiety (light-dark test and elevated plus-maze test). (S)-UH-301 antagonized various symptoms and behaviors induced by the selective 5HT1A receptor agonist 8-OH-DPAT, such as lower lip retraction and flat body posture in rats, hyperphagia for palatable food in rats, and displacement activities (considered as indices of anxiety) in squirrel monkeys. These results further characterize (S)-UH-301 as an in vivo active 5HT1A receptor antagonist and suggest that this antagonistic activity might confer the compound with anxiolytic-like properties.
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
April 2002,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
January 1996,
Journal of neural transmission (Vienna, Austria : 1996),
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
September 1996,
Pharmacology, biochemistry, and behavior,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
June 1992,
European journal of pharmacology,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
January 1994,
Journal of neural transmission. General section,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
February 1996,
Protein engineering,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
September 1991,
European journal of pharmacology,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
July 1991,
European journal of pharmacology,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
February 2000,
International journal of pharmaceutics,
J L Moreau, and
G Griebel, and
F Jenck, and
J R Martin, and
U Widmer, and
W E Haefely
May 1996,
Naunyn-Schmiedeberg's archives of pharmacology,
