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Comparison of the dynamics of resistance-associated mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors after cessation of antiretroviral combination therapy. 2004
Marc Wirden, and
Constance Delaugerre, and
Anne Genevieve Marcelin, and
Nadine Ktorza, and
Hocine Ait Mohand, and
Stephanie Dominguez, and
Luminita Schneider, and
Jade Ghosn, and
Michele Pauchard, and
Dominique Costagliola, and
Christine Katlama, and
Vincent Calvez
Department of Virology, INSERM EMI 0214, Pitié-Salpêtrière Hospital, Paris, France. marc.wirden@psl.ap-hop-paris.fr
The dynamics of mutations associated with resistance to antiretroviral drugs were analyzed after cessation of therapy. The results showed that the kinetics of the shift to wild-type amino acid residues were significantly faster for protease inhibitors, intermediate for nonnucleoside reverse transcriptase inhibitors, and slower for nucleoside reverse transcriptase inhibitors.
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