Biomaterial Database

Regulation of MAPK cascades by protein tyrosine phosphatases. 2004

Josema Torres, and Carmen Blanco-Aparicio, and Rafael Pulido

Instituto de Investigaciones Citológicas, Valencia, Spain.

UI	MeSH Term	Description	Entries
D011993	Recombinant Fusion Proteins	Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.	Fusion Proteins, Recombinant,Recombinant Chimeric Protein,Recombinant Fusion Protein,Recombinant Hybrid Protein,Chimeric Proteins, Recombinant,Hybrid Proteins, Recombinant,Recombinant Chimeric Proteins,Recombinant Hybrid Proteins,Chimeric Protein, Recombinant,Fusion Protein, Recombinant,Hybrid Protein, Recombinant,Protein, Recombinant Chimeric,Protein, Recombinant Fusion,Protein, Recombinant Hybrid,Proteins, Recombinant Chimeric,Proteins, Recombinant Fusion,Proteins, Recombinant Hybrid
D002460	Cell Line	Established cell cultures that have the potential to propagate indefinitely.	Cell Lines,Line, Cell,Lines, Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014162	Transfection	The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.	Transfections
D017027	Protein Tyrosine Phosphatases	An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.	Phosphotyrosine Phosphatase,Protein-Tyrosine-Phosphatase,Tyrosyl Phosphoprotein Phosphatase,PTPase,Phosphotyrosyl Protein Phosphatase,Protein-Tyrosine Phosphatase,Phosphatase, Phosphotyrosine,Phosphatase, Phosphotyrosyl Protein,Phosphatase, Protein-Tyrosine,Phosphatase, Tyrosyl Phosphoprotein,Phosphatases, Protein Tyrosine,Phosphoprotein Phosphatase, Tyrosyl,Protein Phosphatase, Phosphotyrosyl,Protein Tyrosine Phosphatase,Tyrosine Phosphatases, Protein
D048055	Mitogen-Activated Protein Kinase 8	A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.	JNK1 Kinase,MAPK8 Mitogen-Activated Protein Kinase,SAP Kinase-1,SAPK1 Mitogen-Activated Protein Kinase,Stress-Activated Protein Kinase 1,Stress-Activated Protein Kinase JNK1,Stress-Activated Protein Kinase gamma,c-jun Kinase-1,c-jun N-Terminal Kinase 1,MAPK8 Mitogen Activated Protein Kinase,Mitogen Activated Protein Kinase 8,SAP Kinase 1,SAPK1 Mitogen Activated Protein Kinase,Stress Activated Protein Kinase 1,Stress Activated Protein Kinase JNK1,Stress Activated Protein Kinase gamma,c jun Kinase 1,c jun N Terminal Kinase 1
D019556	COS Cells	CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CHLOROCEBUS AETHIOPS).)	COS-1 Cells,COS-7 Cells,COS 1 Cells,COS 7 Cells,COS Cell,COS-1 Cell,COS-7 Cell,Cell, COS,Cell, COS-1,Cell, COS-7,Cells, COS,Cells, COS-1,Cells, COS-7
D019950	Mitogen-Activated Protein Kinase 1	A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.	Extracellular Signal-Regulated Kinase 2,MAP Kinase 2,Mitogen-Activated Protein Kinase 2,p42 MAP Kinase,p42 MAPK,p42(Mitogen-Activated Protein Kinase),MAPK1 Mitogen-Activated Protein Kinase,MAPK2 Mitogen-Activated Protein Kinase,p42(Mapk),p42(Mapk) Kinase,Extracellular Signal Regulated Kinase 2,MAP Kinase, p42,MAPK1 Mitogen Activated Protein Kinase,MAPK2 Mitogen Activated Protein Kinase,Mitogen Activated Protein Kinase 1,Mitogen Activated Protein Kinase 2
D020928	Mitogen-Activated Protein Kinases	A superfamily of PROTEIN SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).	Mitogen Activated Protein Kinase,Mitogen-Activated Protein Kinase,Kinase, Mitogen-Activated Protein,Kinases, Mitogen-Activated Protein,Mitogen Activated Protein Kinases,Protein Kinase, Mitogen-Activated,Protein Kinases, Mitogen-Activated