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In order to determine the effect of Alzheimer's disease on the relative distribution of soluble and membrane-bound molecular forms of acetylcholinesterase (AChE) in the brain, postmortem samples (delay interval less than 12 h) were obtained from parietal cortex (Brodmann area 40) and hippocampus as well as the areas containing their respective projection nuclei, i.e., substantia innominata and septal nucleus, in 9 patients with Alzheimer's disease (AD) and 4 normal controls. The monomer (G1), dimer (G2), and tetramer (G4) forms of AChE were examined. In AD compared to controls, significant changes occurred in area 40 and hippocampus but not in the areas containing projection nuclei, and included loss of mean total AChE activity, decrease in the relative percentage of membrane-bound G4, and increase in the relative percentage of soluble G1-G2. Percent of soluble G4 was unaffected in AD brain. In area 40 but not hippocampus a large increase in percent membrane-bound G1-G2 occurred. Thus, these results emphasize that the selective decrease in membrane-bound G4 accounts for the decrease in total G4 activity in AD brain.
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
November 1990,
Neurochemical research,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
October 1990,
Neuroscience letters,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
November 1979,
Journal of neurochemistry,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
September 1987,
Brain research,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
January 1976,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
January 1981,
Zeitschrift fur Naturforschung. Section C, Biosciences,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
January 1983,
Journal of neurochemistry,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
January 1984,
Life sciences,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
July 1994,
Neurochemical research,
K M Schegg, and
L S Harrington, and
S Neilsen, and
R M Zweig, and
J H Peacock
December 1973,
FEBS letters,
