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In order to observe acetylcholinesterase (AChE) and its distribution into soluble and membrane-bound molecular forms in cholinergically denervated hippocampus, AChE was analyzed in the hippocampus of adult mice with and without bilateral fornix lesions made by stereotactically positioned knife cuts. Homogenates from lesioned mice contained an average of 3% of choline acetyltransferase-specific activity, 12% of AChE-specific activity and 98% of protein compared to homogenates from controls. After lesioning, the relative proportion of membrane-bound G4 decreased from 77% to 56% of total AChE while soluble G4, membrane-bound G1-G2, and soluble G1-G2 each increased in relative abundance.
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
January 1985,
Biology of the cell,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
January 1992,
Neurobiology of aging,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
April 1979,
Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
January 1983,
Enzyme,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
October 1976,
FEBS letters,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
November 1990,
Neurochemical research,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
January 1981,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
January 1981,
Zeitschrift fur Naturforschung. Section C, Biosciences,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
February 1996,
Brain research,
K M Schegg, and
R P Gillespie, and
U Prym, and
J H Peacock
July 1994,
Neurochemical research,
