-transparent.png){kind=logo}
1. Suspension cultures of freshly isolated F344 rat and B6C3F1 mouse hepatocytes were compared for their ability to transform various concentrations of methapyrilene (MP). 2. MP metabolites were isolated and purified by h.p.l.c., and were identified by comparing their chromatographic and mass spectral properties with those of authentic standards. 3. Both rat and mouse hepatocytes transformed MP to tentatively identified 2-thiophenecarboxylic acid (I), and definitively identified mono-N-desmethyl methapyrilene glucuronide (II), methapyrilene glucuronide (III), methapyrilene N-oxide (V), and mono-N-desmethyl methapyrilene (VII).
Related Publications
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
January 1984,
Drug metabolism and disposition: the biological fate of chemicals,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
February 2004,
Xenobiotica; the fate of foreign compounds in biological systems,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
January 2019,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
January 1981,
Drug metabolism and disposition: the biological fate of chemicals,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
April 1998,
Toxicology and applied pharmacology,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
October 1985,
Toxicology,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
February 1998,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
January 2005,
Journal of analytical toxicology,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
April 1987,
Toxicology and applied pharmacology,
D W Kelly, and
C L Holder, and
W A Korfmacher, and
T A Getek, and
J O Lay, and
D A Casciano, and
J G Shaddock, and
H M Duhart, and
W Slikker
March 1997,
Drug metabolism and disposition: the biological fate of chemicals,
