Impaired recency judgments and intact novelty judgments after fornix transection in monkeys. 2004

David P Charles, and David Gaffan, and Mark J Buckley
Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom. david.charles@psy.ox.ac.uk

Over four experiments based on the delayed matching-to-sample task, fornix-transected and normal control monkeys were presented with a sequence of five sample stimuli and then received intermixed within-session recency (WSR) and between-session recency (BSR) tests in experiment 1, only BSR tests in experiment 2, only absolute novelty (AN) tests in experiment 3, or only WSR tests in experiment 4. In WSR tests, monkeys chose which of two samples had occurred more recently in the immediately preceding sequence. In BSR and AN tests, monkeys were required to choose one sample from the immediately preceding sequence in preference to a foil unseen in the present session (BSR) or an AN foil that had never been presented before. When tests of WSR and BSR were intermixed (experiment 1), fornix monkeys performed below the level of the control monkeys in both types of test, although this difference was not statistically significant. In experiment 2, fornix monkeys were significantly impaired on tests of BSR alone, in which memory for a stimulus presented in an immediately preceding sequence could compete with memory for a foil presented in an earlier training session. In tests of AN (experiment 3), fornix monkeys performed at the same level as control animals in distinguishing a previously experienced stimulus from a previously unseen foil. In experiment 4, fornix transection significantly impaired tests of WSR alone. Taken together, these results suggest that one specialized role of the fornix is to process temporal information.

UI MeSH Term Description Entries
D007600 Judgment The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation. Judgement,Judgements,Judgments
D008253 Macaca mulatta A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans. Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D008297 Male Males
D010364 Pattern Recognition, Visual Mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs. Recognition, Visual Pattern,Visual Pattern Recognition
D010775 Photic Stimulation Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity. Stimulation, Photic,Visual Stimulation,Photic Stimulations,Stimulation, Visual,Stimulations, Photic,Stimulations, Visual,Visual Stimulations
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D013647 Task Performance and Analysis The detailed examination of observable activity or behavior associated with the execution or completion of a required function or unit of work. Critical Incident Technique,Critical Incident Technic,Task Performance,Task Performance, Analysis,Critical Incident Technics,Critical Incident Techniques,Incident Technic, Critical,Incident Technics, Critical,Incident Technique, Critical,Incident Techniques, Critical,Performance, Analysis Task,Performance, Task,Performances, Analysis Task,Performances, Task,Task Performances,Task Performances, Analysis,Technic, Critical Incident,Technics, Critical Incident,Technique, Critical Incident,Techniques, Critical Incident
D013998 Time Perception The ability to estimate periods of time lapsed or duration of time. Temporal Perception,Temporal Processing,Time Processing,Perception, Temporal,Perception, Time,Processing, Temporal,Processing, Time

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