Biomaterial Database

Does amnesia after transection of the fornix in monkeys reflect abnormal sensitivity to proactive interference? 1984

M J Owen, and S R Butler

Monkeys in whom the fornix had been transected and controls were tested in two versions of delayed non-matching to sample (DNMS). On DNMS-LSS both of the stimuli for each trial were selected from a large set of junk objects that were already familiar to the subjects. On DNMS-CSN the new stimulus at the retention test of each trial was one which the animals had never encountered before. Memory for the sample was assessed with retention intervals of 10, 70 and 130 s. In DNMS-LSS the lesioned animals were impaired, being more susceptible than controls to increases in the retention interval. However, no impairment in DNMS-CSN was observed. The abnormally fast forgetting by lesioned animals in DNMS-LSS seems therefore to reflect abnormal sensitivity to proactive interference. The results are compared with similar findings from amnesic humans and their implications for theoretical accounts of the effects of hippocampal disruption are discussed.

UI	MeSH Term	Description	Entries
D008253	Macaca mulatta	A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.	Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D008326	Mammillary Bodies	A pair of nuclei and associated GRAY MATTER in the interpeduncular space rostral to the posterior perforated substance in the POSTERIOR HYPOTHALAMUS.	Mamillary Bodies,Bodies, Mamillary,Bodies, Mammillary,Body, Mamillary,Body, Mammillary,Mamillary Body,Mammillary Body
D008568	Memory	Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D009434	Neural Pathways	Neural tracts connecting one part of the nervous system with another.	Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D012153	Retention, Psychology	The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.	Psychological Retention,Retention (Psychology),Psychology Retention,Retention, Psychological
D001931	Brain Mapping	Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.	Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D003214	Conditioning, Classical	Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.	Reflex, Conditioned,Classical Conditioning,Classical Conditionings,Conditioned Reflex,Conditionings, Classical
D005260	Female		Females
D006624	Hippocampus	A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.	Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man