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This study was designed to determine the effects of an aluminum hydroxide antacid and a calcium carbonate antacid on the bioavailability of ciprofloxacin (Cipro). Cipro (750 mg) was administered orally to 12 healthy volunteers in a three-way randomized crossover design. The three treatments included Cipro alone, four 850-mg calcium carbonate tablets taken 5 min before Cipro, and three 600-mg aluminum hydroxide tablets taken 5 min before Cipro. The relative bioavailability of Cipro when given with calcium carbonate was approximately 60% of the control value. When Cipro was given with aluminum hydroxide, the relative bioavailability was approximately 15%. Urinary recovery of Cipro in the aluminum hydroxide treatment group was approximately one-fourth of that in the calcium carbonate group. Although calcium carbonate decreased absorption to a lesser extent than aluminum hydroxide, these data suggest that antacids containing either aluminum or calcium should not be given concomitantly with Cipro.
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
December 1990,
Antimicrobial agents and chemotherapy,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
April 1988,
Digestive diseases and sciences,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
January 1943,
The Journal of clinical investigation,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
December 1989,
Clinical pharmacology and therapeutics,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
April 1960,
Journal of the American Pharmaceutical Association. American Pharmaceutical Association,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
January 1986,
ASAIO transactions,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
February 1996,
Clinical nephrology,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
December 1983,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
November 2007,
Clinical journal of the American Society of Nephrology : CJASN,
R W Frost, and
K C Lasseter, and
A J Noe, and
E C Shamblen, and
J T Lettieri
January 1988,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
