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An improved synthesis of N2-protected-3'-azido-2',3'-dideoxyguanosine 20 and 23 is described. Deoxygenation of 2'-O-alkyl (and/or aryl) sulfonyl-5'-dimethoxytritylguanosine coupled with [1,2]-hydride shift rearrangement gave protected 9-(2-deoxythreo-pentofuranosyl)guanines (10, 12 and 16). This rearrangement was accomplished in high yield with a high degree of stereoselectivity using lithium triisobutylborohydride (L-Selectride). Compounds 10, 12 and 16 were transformed into 3'-O-mesylates (18 and 21), which can be used for 3'-substitution. The 3'-azido nucleosides were obtained by treatment of 18 and 21 with lithium azide. This procedure is reproducible with a good overall yield.
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 2000,
Nucleosides, nucleotides & nucleic acids,
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 1990,
Biochemical and biophysical research communications,
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 2014,
Antiviral research,
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 1987,
Lancet (London, England),
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 2005,
Nucleosides, nucleotides & nucleic acids,
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
June 1987,
Biochemical and biophysical research communications,
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 2008,
Nucleic acids symposium series (2004),
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
November 1991,
The Journal of infectious diseases,
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 2009,
Nucleic acids symposium series (2004),
Victor A Timoshchuk, and
Richard I Hogrefe, and
Morteza M Vaghefi
January 2020,
Nucleosides, nucleotides & nucleic acids,
