BIOMAT Database Logo BIOMAT Database Logo

Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum. 2004

Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hedge@spcorp.com

The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC(50) of 4 and 5 microM, respectively.

UI MeSH Term Description Entries
D004791 Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D001419 Bacteria One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive. Eubacteria
D013057 Spectrum Analysis The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Spectroscopy,Analysis, Spectrum,Spectrometry
D045468 Fallopia japonica A plant species of the family POLYGONACEAE. Itadori tea is prepared from the root of this genus. Polygonum cuspidatum,Japanese Knotweed,Knotweed, Japanese,Fallopia japonicas,Japanese Knotweeds,Knotweeds, Japanese,Polygonum cuspidatums,cuspidatum, Polygonum,japonicas, Fallopia
D019915 DNA Primase A single-stranded DNA-dependent RNA polymerase that functions to initiate, or prime, DNA synthesis by synthesizing oligoribonucleotide primers. EC 2.7.7.-. Primase,Bacteriophage T7 Gene 4 Protein,DnaG (Primase),DnaG Gene Product,DnaG Protein,T7 DNA Primase-Helicase Protein,T7 DNA-Priming Protein,T7 gene-4 protein,DNA-Priming Protein, T7,Primase, DNA,Protein, T7 DNA-Priming,T7 DNA Primase Helicase Protein,T7 DNA Priming Protein,T7 gene 4 protein

Related Publications

Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Two new anthraquinone malonylglucosides from Polygonum cuspidatum.
January 2012, Natural product research,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Kinase inhibitors from Polygonum cuspidatum.
October 1993, Journal of natural products,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
New phenolic glycosides from Polygonum cuspidatum.
January 2020, Journal of Asian natural products research,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Potent bacterial neuraminidase inhibitors, anthraquinone glucosides from Polygonum cuspidatum and their inhibitory mechanism.
December 2016, Journal of ethnopharmacology,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Constituents from Polygonum cuspidatum.
May 2002, Chemical & pharmaceutical bulletin,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use.
April 2008, Phytotherapy research : PTR,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Bioactive amides from Polygonum cuspidatum.
March 2021, Journal of Asian natural products research,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Stilbene glycoside sulfates from Polygonum cuspidatum.
October 2000, Journal of natural products,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
New Constitutents of Roots of Polygonum cuspidatum.
July 1983, Planta medica,
Vinod R Hegde, and Haiyan Pu, and Mahesh Patel, and Todd Black, and Aileen Soriano, and Wenjun Zhao, and Vincent P Gullo, and Tze-Ming Chan
Antitumor Research of the Active Ingredients from Traditional Chinese Medical Plant Polygonum Cuspidatum.
January 2018, Evidence-based complementary and alternative medicine : eCAM,
Copied contents to your clipboard!