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New phenolic glycosides from Polygonum cuspidatum. 2020

Jian-Shuang Jiang, and Fu-Shuang Li, and Zi-Ming Feng, and Ya-Nan Yang, and Pei-Cheng Zhang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Two new isobenzofuranone derivatives, polyphthaliside A (1) and polyphthaliside B (2), and a new isocoumarin derivative, polyisocoumarin (3), were isolated from Polygonum cuspidatum. Their structures were elucidated by detailed spectroscopic analysis and chemical methods. The cytotoxicity activity and PTP1B inhibitory activity of compounds 1-3 were estimated and none of them exhibited activities at a concentration of 10 μM.

UI MeSH Term Description Entries
D010636 Phenols Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D006027 Glycosides Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed) Glycoside
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D045468 Fallopia japonica A plant species of the family POLYGONACEAE. Itadori tea is prepared from the root of this genus. Polygonum cuspidatum,Japanese Knotweed,Knotweed, Japanese,Fallopia japonicas,Japanese Knotweeds,Knotweeds, Japanese,Polygonum cuspidatums,cuspidatum, Polygonum,japonicas, Fallopia
D049934 Isocoumarins Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule. Isocoumarin,1-Isochromen-1-ones,1H-2-Benzopyran-1-ones
D028502 Polygonum A plant genus of the family POLYGONACEAE that is an ingredient of Shou-Wu-Pian, a Chinese herbal preparation (DRUGS, CHINESE HERBAL). The common name of black bindweed also refers to TAMUS or Fallopia (use POLYGONACEAE). Bistort,Buckwheat, False,Knotweed,Smartweed,Bistorts,Buckwheats, False,False Buckwheat,False Buckwheats,Knotweeds,Polygonums,Smartweeds

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