-transparent.png){kind=logo}
Determination of baicalin and baicalein in rat plasma by high-performance liquid chromatography with electrochemical detection. 1992
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
Research Institute for Pharmacology, Tsumura & Co., Ibaraki, Japan.
A rapid and sensitive method, using electrochemical detection, has been developed for the determination of baicalin and baicalein, the flavonoid of Scutellariae radix, in rat plasma. Following separation by high-performance liquid chromatography, baicalin and baicalein were oxidized at a glassy carbon electrode to permit selective electrochemical detection. Absolute detection limits were found to be 5 ng/ml from 50 microliters of plasma for baicalin and 2 ng/ml from 100 microliters of plasma for baicalein. The resulting assays were suitable for pharmacokinetic studies of baicalin and baicalein in rats.
Related Publications
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
April 1996,
Journal of chromatography. B, Biomedical applications,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
February 1985,
Journal of chromatography,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
January 1992,
Journal of chromatography,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
March 1978,
Journal of chromatography,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
May 1993,
Journal of chromatography,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
January 2006,
Biomedical chromatography : BMC,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
May 1998,
Journal of chromatography. B, Biomedical sciences and applications,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
July 1999,
Journal of chromatography. B, Biomedical sciences and applications,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
October 1998,
Journal of chromatography. B, Biomedical sciences and applications,
Y Wakui, and
E Yanagisawa, and
E Ishibashi, and
Y Matsuzaki, and
S Takeda, and
H Sasaki, and
M Aburada, and
T Oyama
September 1988,
Journal of chromatography,
