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We report a sensitive new method for the determination of timiperone in rat plasma by using high-performance liquid chromatography with electrochemical detection. The method involves extraction of plasma samples with heptane-isoamyl alcohol at pH > 8, followed by back-extraction into dilute acetic acid. Separation was accomplished by reversed-phase high-performance liquid chromatography on an ODS column with the mobile phase consisting of 0.1 M phosphate buffer (pH 3.5)-acetonitrile-methanol (65:20:15, v/v). Recovery was greater than 80%. Calibration curve was linear over the concentration range 0.5-50.0 ng/ml. The limit of quantitation of timiperone was 0.5 ng/ml plasma.
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
January 1992,
Journal of chromatography,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
March 1978,
Journal of chromatography,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
May 1993,
Journal of chromatography,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
January 2006,
Biomedical chromatography : BMC,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
March 1992,
Journal of chromatography,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
February 1985,
Journal of chromatography,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
July 1999,
Journal of chromatography. B, Biomedical sciences and applications,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
October 1998,
Journal of chromatography. B, Biomedical sciences and applications,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
September 1988,
Journal of chromatography,
T Takayasu, and
I Kakubari, and
A Fukamachi, and
E Mafune, and
N Takasugi, and
K Takayama, and
T Nagai
January 1991,
Journal of chromatography,
