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Platelet-derived growth factors (PDGFs) are growth-regulatory molecules that stimulate chemotaxis, proliferation and increased metabolism, primarily of connective tissue cells. In our previous paper, we have demonstrated the ubiquitous localization of PDGF B-chain-containing proteins in neurons and expression of transcripts for PDGF A-chain, B-chain and the two forms of the PDGF receptor in the brains of non-human primates. In the present study, the cellular localization of PDGF B-chain in developing and adult rat brains was analyzed using immunocytochemistry with a PDGF B-chain-specific monoclonal antibody. Intense PDGF B-chain immunoreactivity (PDGFB-I) was distributed around the continuously regenerating primary olfactory neurons at all stages of development from embryo to adult. The major part of PDGFB-I associated with neurons appeared some time after birth and increased with age. PDGFB-I appeared in several nerve fiber systems during earlier stages of development and gradually decreased with age. In conjunction with other data showing the existence of functional PDGF receptor beta-subunits in the neurons, these data suggest a possible role for PDGF B-chain as a neurotrophic or neuroregulatory factor in both developing and mature brains.
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
August 1994,
Brain research,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
September 1991,
Brain research,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
August 1995,
Brain research. Molecular brain research,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
March 1998,
Oncogene,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
May 1995,
Neuroscience,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
July 1994,
Brain research,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
December 1981,
Brain research bulletin,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
November 1998,
Journal of dermatological science,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
December 1993,
Laboratory investigation; a journal of technical methods and pathology,
A Sasahara, and
J N Kott, and
M Sasahara, and
E W Raines, and
R Ross, and
L E Westrum
March 1999,
Brain research,
