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A semi-industrial process (800-l fermentor) for lycopene production by mated fermentation of Blakeslea trispora plus (+) and minus (-) strains has been developed. The culture medium was designed at the flask scale, using a program based on a genetic algorithm; and a fermentation process by means of this medium was developed. Fermentation involves separate vegetative phases for (+) and (-) strains and inoculation of the production medium with a mix of both together. Feeding with imidazole or pyridine, molecules known to inhibit lycopene cyclase enzymatic activity, enhanced lycopene accumulation. Different raw materials and physical parameters, including dissolved oxygen, stirring speed, air flow rate, temperature, and pH, were checked in the fermentor to get maximum lycopene production. Typical data for the fermentation process are presented and discussed. This technology can be easily scaled-up to an industrial application for the production of this carotenoid nowadays widely in demand.
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
January 2018,
Methods in molecular biology (Clifton, N.J.),
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
April 2019,
Foods (Basel, Switzerland),
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
May 2012,
Bioprocess and biosystems engineering,
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
January 2014,
Zeitschrift fur Naturforschung. C, Journal of biosciences,
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
May 2012,
Biotechnology letters,
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
March 1962,
Applied microbiology,
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
October 2012,
Molecules (Basel, Switzerland),
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
January 2015,
Applied biochemistry and biotechnology,
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
December 2013,
Applied biochemistry and biotechnology,
M J López-Nieto, and
J Costa, and
E Peiro, and
E Méndez, and
M Rodríguez-Sáiz, and
J L de la Fuente, and
W Cabri, and
J L Barredo
January 1972,
Archiv fur Mikrobiologie,
