BIOMAT Database Logo BIOMAT Database Logo

C-H...O hydrogen bonds in beta-sheets. 1997

G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
Department of Crystallography and Biophysics, University of Madras, India.

A detailed analysis of the occurrence of the C-H...O hydrogen bonds in sheet regions of proteins has been presented. 11 unique protein structures with resolution 1.3 A containing beta-sheets show a widespread presence of C-H...O hydrogen bonds. These have average C(alpha).O, CH...O distances and a C(alpha)-H...O angle of 3.29, 2.38 A and 143 degrees, respectively. As in the case of N-H...O hydrogen bonds, parallel and antiparallel beta-sheet regions show the same hydrogen-bond geometry. An inverse correlation is observed between the hydrogen-bond geometries involving the C(alpha)(i)-H...O=C and the N(i+1)-H...O=C suggesting that C-H...O hydrogen bonds may act as an additional stabilizing factor. The propensity of different amino-acid residues to form such hydrogen bonds varies and shows a clear preference for valine and threonine. C-H...O hydrogen bonds involving side chains also occur extensively in beta-sheet regions.

UI MeSH Term Description Entries

Related Publications

G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
Isomeric nitrophthalimides: sheets built from N-H...O and C-H...O hydrogen bonds.
December 2004, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
3-nitrophthalic acid: C(4) and R(2)(2)(8) motifs of O-H...O hydrogen bonds generate sheets which are linked by C-H...O hydrogen bonds.
March 2003, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
4-Nitrophenyl phenyl ether: sheets built from C-H...O and C-H...pi(arene) hydrogen bonds.
March 2005, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
3-Nitrobenzaldehyde isonicotinoylhydrazone monohydrate redetermined at 120 K: sheets built from O-H...O, O-H...N, N-H...O and C-H...O hydrogen bonds.
January 2007, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
Ferrocenecarboxylic acid-1,4-diazabicyclo[2.2.2]octane (2/1): sheets built from O--H...N and C--H...O hydrogen bonds.
June 2001, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
2-Aminobenzimidazolium O-ethyl malonate: eight independent N-H...O hydrogen bonds generate sheets.
December 2003, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
C─H⋯O hydrogen bonds in kinase-inhibitor interfaces.
June 2020, IUBMB life,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
2-Cyano-N-(4,6-dimethoxypyrimidin-2-yl)acetamide: complex sheets built from N-H...O and C-H...O hydrogen bonds.
October 2010, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
4-iodoanilinium 3-nitrophthalate(1-): tripartite sheets built from O-H...O and N-H...O hydrogen bonds.
September 2003, Acta crystallographica. Section C, Crystal structure communications,
G F Fabiola, and S Krishnaswamy, and V Nagarajan, and V Pattabhi
5-Amino-1-benzoyl-3-methylpyrazole: complex sheets built from N-H...N, C-H...O and C-H...pi(arene) hydrogen bonds.
April 2010, Acta crystallographica. Section C, Crystal structure communications,
Copied contents to your clipboard!