BIOMAT Database Logo BIOMAT Database Logo

Identification of an anion-transport ATPase that catalyzes glutathione conjugate-dependent ATP hydrolysis in canalicular plasma membranes from normal rats and rats with conjugated hyperbilirubinemia (GY mutant). 1992

P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock 72205.

Rat liver canalicular plasma membranes were found to contain a 37-kDa protein that is immunologically cross-reactive with the dinitrophenyl glutathione-stimulated ATPase previously identified in human tissues. The protein, which was partially purified by affinity chromatography, exhibited ATPase activity dependent on dinitrophenyl glutathione, bilirubin ditaurate, and other dianionic compounds. The localization of this protein in the canalicular membrane and its measured enzymatic activity indicate that it is involved in the transport of glutathione derivatives and other dianionic organic compounds. A rat mutant in which the above transport activities are impaired contained the protein in amounts similar to those in a normal control.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008970 Molecular Weight The sum of the weight of all the atoms in a molecule. Molecular Weights,Weight, Molecular,Weights, Molecular
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D011922 Rats, Mutant Strains Rats bearing mutant genes which are phenotypically expressed in the animals. Mutant Strains Rat,Mutant Strains Rats,Rat, Mutant Strains,Strains Rat, Mutant,Strains Rats, Mutant
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002352 Carrier Proteins Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D002846 Chromatography, Affinity A chromatographic technique that utilizes the ability of biological molecules, often ANTIBODIES, to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Chromatography, Bioaffinity,Immunochromatography,Affinity Chromatography,Bioaffinity Chromatography

Related Publications

P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.
May 1990, Proceedings of the National Academy of Sciences of the United States of America,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
ATP-dependent organic anion transport system in normal and TR- rat liver canalicular membranes.
April 1992, The American journal of physiology,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia.
January 1991, Life sciences,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Gender related differences in ATP-dependent transport of dinitrophenyl-glutathione conjugate across murine canalicular liver plasma membrane.
February 1999, FEBS letters,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes.
May 1990, The Journal of biological chemistry,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.
January 1992, The Journal of biological chemistry,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia.
August 1989, The Journal of clinical investigation,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport.
January 1985, Hepatology (Baltimore, Md.),
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
Hereditary conjugated hyperbilirubinemia in Wistar rats: a model for the study of ATP-dependent hepatocanalicular organic anion transport.
January 1993, Advances in veterinary science and comparative medicine,
P Zimniak, and S A Ziller, and I Panfil, and A Radominska, and H Wolters, and F Kuipers, and R Sharma, and M Saxena, and M T Moslen, and M Vore
ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver.
July 1991, The Journal of biological chemistry,
Copied contents to your clipboard!