-transparent.png){kind=logo}
Neonatal T cells are phenotypically similar to "naive" T cells from adult donors in the CD45 isoform expression. Despite the phenotypic similarity, large differences were found between neonatal and adult T cells when T cells were activated. After activation with PHA, adult CD45RA+ T cells began to express CD45RO and no loss of CD45RA expression had yet occurred at Day 3 post-stimulation. Three days after activation, CD45RA+ neonatal T cells also coexpressed CD45RO; however, in contrast to adult T cells, a marked loss of CD45RA was observed. We analyzed the rapid loss of CD45RA found in neonatal T cells. The de novo synthesis of CD45 isoforms in neonatal T cells was essentially the same as that in the adult T cells. Turnover of the CD45RA was very rapid in both resting adult and neonatal T cells. After activation with PHA, the turnover of CD45RA on adult T cells was decreased significantly, while the turnover of CD45RA on neonatal T cells was not changed after activation. Therefore, the regulation of CD45 isoform expression not only involves switches in alternative splicing, but also involves different regulation of turnover of these isoforms from the cell membrane.
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
August 1990,
European journal of immunology,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
June 2012,
Medical oncology (Northwood, London, England),
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
December 1991,
Annals of the New York Academy of Sciences,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
August 1996,
The Journal of allergy and clinical immunology,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
September 1989,
Proceedings of the National Academy of Sciences of the United States of America,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
September 1994,
British journal of haematology,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
October 1993,
Blood,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
January 1993,
Immunologic research,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
February 1992,
Seminars in immunology,
A Yamada, and
T Kaneyuki, and
A Hara, and
D M Rothstein, and
M M Yokoyama
July 1991,
International immunology,
