-transparent.png){kind=logo}
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1. 2005
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
Medicinal Chemistry Department, Johnson & Johnson Pharmaceutical Research and Development, Campus de Maigremont BP615, Val de Reuil, France. jguillem@prdfr.jnj.com
This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY) compounds as nonnucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis program around this new DAPY series was further optimized to produce compounds displaying improved activity against a panel of eight clinically relevant single and double mutant strains of human immunodeficiency virus type 1 (HIV-1).
Related Publications
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
December 1988,
Gene,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
August 1990,
Journal of medicinal chemistry,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
June 1991,
Chemical & pharmaceutical bulletin,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
January 1996,
Phytomedicine : international journal of phytotherapy and phytopharmacology,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
March 2001,
Bioscience, biotechnology, and biochemistry,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
January 2002,
Phytomedicine : international journal of phytotherapy and phytopharmacology,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
February 1988,
Journal of medicinal chemistry,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
April 1995,
AIDS research and human retroviruses,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
August 2005,
The Journal of general virology,
Jerome Guillemont, and
Elisabeth Pasquier, and
Patrice Palandjian, and
Daniel Vernier, and
Sandrine Gaurrand, and
Paul J Lewi, and
Jan Heeres, and
Marc R de Jonge, and
Lucien M H Koymans, and
Frits F D Daeyaert, and
Maarten H Vinkers, and
Eddy Arnold, and
Kalyan Das, and
Rudi Pauwels, and
Koen Andries, and
Marie-Pierre de Béthune, and
Eva Bettens, and
Kurt Hertogs, and
Piet Wigerinck, and
Philip Timmerman, and
Paul A J Janssen
June 2004,
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,
