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Regioselective one-pot synthesis of 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines. Reactivity of aliphatic and aromatic hydrazides. 2005
Asier Unciti-Broceta, and
Maria J Pineda-de-las-Infantas, and
Juan J Díaz-Mochón, and
Romeo Romagnoli, and
Pier G Baraldi, and
Miguel A Gallo, and
Antonio Espinosa
Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Campus Cartuja s/n, 18071 Granada, Spain.
[reaction: see text] The one-pot synthesis of new 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines has been achieved. Hydrazides regioselectively reacted as nucleophiles with the 3-chloro substituent of 2,3-dichloropyrido[2,3-b]pyrazine. An intramolecular cyclization afforded the tricycle nonxanthine adenosine receptor antagonists.
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