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An entry to a chiral dihydropyrazole scaffold: enantioselective [3 + 2] cycloaddition of nitrile imines. 2005

Mukund P Sibi, and Levi M Stanley, and Craig P Jasperse
Department of Chemistry, North Dakota State University, Fargo, ND 58105, USA.

We have developed a versatile strategy to access dihydropyrazoles in highly enantioenriched form. Dipolar cycloaddition of electron-deficient acceptors and in situ-generated nitrile imines proceeds with high regio- and enantioselectivity using 10 mol % chiral Lewis acid catalyst. A variety of dihydropyrazoles that incorporate functionality for further manipulation have been prepared.

UI MeSH Term Description Entries

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