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The purpose of this study was to evaluate the photosensitizing dye merocyanine 540 (MC540) as a means for extracorporeal purging of Plasmodium falciparum-infected erythrocytes from human blood. Parasitized red blood cells bound more dye than nonparasitized cells, and exposure to MC540 and light under conditions that are relatively well tolerated by normal erythrocytes and normal pluripotent hematopoietic stem cells reduced the concentration of parasitized cells by as much as 1,000-fold. Cells parasitized by the chloroquine-sensitive HB3 clone and the chloroquine-resistant Dd2 clone of P falciparum were equally susceptible to MC540-sensitized photolysis. These data suggest the potential usefulness of MC540 in the purging of P falciparum-infected blood.
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
October 1992,
Photochemistry and photobiology,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
February 1983,
The Journal of parasitology,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
November 1992,
Archives of biochemistry and biophysics,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
January 1996,
Molecular and biochemical parasitology,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
August 1992,
Photochemistry and photobiology,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
December 1990,
Cancer research,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
July 1992,
Blood,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
February 2001,
Photochemistry and photobiology,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
January 1992,
Blood cells,
O M Smith, and
S A Dolan, and
J A Dvorak, and
T E Wellems, and
F Sieber
March 1991,
Biochimica et biophysica acta,
