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The changes of population spike(PS)/population excitatory postsynaptic potential (EPSP) slope relationship and paired-pulse facilitation (PPF) were primarily investigated with extracellular recording in stratum pyramidale to stimulation of Schaffer collaterals in CA1 region of hippocampal slices from coriaria lactone (CL)-kindled and control rats. The results were as follows: (1) neither spontaneous nor evoked epileptiform bursts were found in all hippocampal slices from CL-kindled and control rats; (2) the synaptic efficacy, expressed by the ratio of PS/EPSP slope, at low stimulation intensity ranging from 10-30% of its maximum was significantly increased on CL-kindled rats (P less than 0.05); and (3) although PPF was found in all slices, the PPF strength only at stimulation intensity of 10 and 20% of maximum was augmented remarkably in CL-kindled rats (P less than 0.002 and 0.024, respectively). According to the results from our previous work, we suggested that the increment of PS/EPSP slope ratio and PPF strength at low stimulation intensity may result from the potentiation of excitatory synaptic activity or/and the change of intrinsic excitability of pyramidal neurons.
L Guo, and
H Chai, and
X Liu, and
Y Xie
February 1997,
Neuroscience,
L Guo, and
H Chai, and
X Liu, and
Y Xie
October 1998,
British journal of pharmacology,
L Guo, and
H Chai, and
X Liu, and
Y Xie
September 1994,
Neuroscience,
L Guo, and
H Chai, and
X Liu, and
Y Xie
July 1994,
Brain research,
L Guo, and
H Chai, and
X Liu, and
Y Xie
June 1987,
Neuroscience letters,
L Guo, and
H Chai, and
X Liu, and
Y Xie
July 1996,
Neuroreport,
L Guo, and
H Chai, and
X Liu, and
Y Xie
May 1993,
Neuroscience letters,
L Guo, and
H Chai, and
X Liu, and
Y Xie
December 1998,
Neuroreport,
L Guo, and
H Chai, and
X Liu, and
Y Xie
October 2005,
Neuroscience research,
L Guo, and
H Chai, and
X Liu, and
Y Xie
November 1996,
Neuroscience letters,
