-transparent.png){kind=logo}
Traumatic brain injury produces significant cognitive deficits in humans. This experiment used a controlled cortical impact model of experimental brain injury to examine the effects of brain injury on spatial learning and memory using the Morris water maze task. Rats (n = 8) were injured at a moderate level of cortical impact injury (6 m/sec, 1.5-2.0 mm deformation). Eight additional rats served as a sham-injured control group. Morris water maze performance was assessed on days 11-15 and 30-34 following injury. Results revealed that brain-injured rats exhibited significant deficits (p less than 0.05) in maze performance at both testing intervals. Since the Morris water maze task is particularly sensitive to hippocampal dysfunction, the results of the present experiment support the hypothesis that the hippocampus is preferentially vulnerable to damage following traumatic brain injury. These results demonstrate that controlled cortical impact brain injury produces enduring cognitive deficits analogous to those observed after human brain injury.
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
September 1997,
Journal of neurotrauma,
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
February 2002,
Brain research,
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
November 2021,
Scientific reports,
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
August 2014,
Journal of visualized experiments : JoVE,
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
August 1998,
Journal of neurotrauma,
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
October 2013,
Brain and cognition,
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
January 2002,
The Journal of neuropsychiatry and clinical neurosciences,
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
March 2013,
BMJ (Clinical research ed.),
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
January 2021,
Methods in molecular biology (Clifton, N.J.),
R J Hamm, and
C E Dixon, and
D M Gbadebo, and
A K Singha, and
L W Jenkins, and
B G Lyeth, and
R L Hayes
January 2018,
Methods in molecular biology (Clifton, N.J.),
