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Synthesis of 5-aza-7-deazaguanine nucleoside derivatives as potential anti-flavivirus agents. 2005
D Dukhan, and
F Leroy, and
J Peyronnet, and
E Bosc, and
D Chaves, and
M Durka, and
R Storer, and
P La Colla, and
F Seela, and
G Gosselin
Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, Montpellier Cedex 5, France.
Coupling suitable sugars (D- or L-ribofuranose, 2' or 3-deoxysugar, branched sugars) with 2-aminoimidazo[1,2-a]-s-triazin-4-one was carried out using the different reaction conditions: 1) condensation in the presence of sodium hydride; or 2) condensation using Vorbrüggen's methods. The 5-aza- 7-deazaguanine nucleoside analogues obtained were evaluated in cell culture experiments for the inhibition of the replication of a number of RNA viruses, including BVDV, YFV, and WNV.
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