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OBJECTIVE The purpose of this study was to evaluate the ability of different methods to induce choroidal neovascularization (CNV) in the domestic pig. METHODS A total of 26 Danish landrace pigs was used. A sample of 22 eyes in 12 pigs underwent retinal photocoagulation with a xenon lamp, six eyes in four pigs underwent retinal photocoagulation with a diode laser, and mechanical rupture of Bruch's membrane (BM) was induced in 12 pigs following surgical debridement of the retinal pigment epithelium without damage to the neuroretina. RESULTS All 12 pigs (100%) in the group with mechanical rupture of BM developed CNV. The induced membranes were morphologically similar to CNV membranes in humans. Induced CNV was found in 13 of 22 (54%) xenon lamp-treated animals and in five of six (83%) diode laser-treated animals. The CNV in these groups was small and the morphology of the induced lesions was dominated by retinal gliosis and retinal neovascularization, probably due to a marked destruction of the neuroretina. CONCLUSIONS Surgical debridement of the retinal pigment epithelium followed by mechanical rupture of BM is a reproducible method of producing CNV in the domestic pig, whereas photocoagulation gives rise to glially derived subretinal fibrovascular membranes and primarily retinal neovascularization.
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
December 2002,
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
April 2023,
Experimental eye research,
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
September 2007,
Archives of ophthalmology (Chicago, Ill. : 1960),
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
February 1989,
Archives of ophthalmology (Chicago, Ill. : 1960),
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
August 2022,
Investigative ophthalmology & visual science,
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
November 2010,
Progress in retinal and eye research,
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
August 2008,
Acta ophthalmologica,
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
June 2006,
Nippon Ganka Gakkai zasshi,
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
September 2014,
Investigative ophthalmology & visual science,
Jens F Kiilgaard, and
Mads Varis Nis Andersen, and
Anne K Wiencke, and
Erik Scherfig, and
Morten la Cour, and
Tongalp H Tezel, and
Jan U Prause
January 2020,
International journal of ophthalmology,
