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Choroidal neovascularization in rat eyes was induced by krypton laser photocoagulation. Lesions were studied weekly by ophthalmoscopy, fundus photography, and fluorescein angiography. Morphologic correlation was provided by serial sectioning of lesions for light and transmission electron microscopy. In addition, vascular casts were prepared for scanning electron microscopy. Choroidal neovascularization occurred in 25 (60%) of 42 lesions, as evidenced by growth of capillaries through breaks in Bruch's membrane. In addition, 24 (28%) of 86 lesions studied by fluorescein angiography demonstrated leakage. This study provides the most complete angiographic, histologic, and ultrastructural documentation of experimental choroidal neovascularization in the rat. This model may be useful for in vivo studies of choroidal angiogenesis and its modulation via drug therapy.
E T Dobi, and
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M Destro
September 1994,
Nippon Ganka Gakkai zasshi,
E T Dobi, and
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December 2005,
Acta ophthalmologica Scandinavica,
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September 2006,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
E T Dobi, and
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June 1999,
Investigative ophthalmology & visual science,
E T Dobi, and
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M Destro
September 2006,
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
E T Dobi, and
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M Destro
December 2002,
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
E T Dobi, and
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February 1983,
International ophthalmology,
E T Dobi, and
C A Puliafito, and
M Destro
October 2010,
Clinical & experimental ophthalmology,
E T Dobi, and
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M Destro
January 2014,
Photomedicine and laser surgery,
E T Dobi, and
C A Puliafito, and
M Destro
January 2015,
Journal of ophthalmic & vision research,
