-transparent.png){kind=logo}
The first successful heterotransplantation of a human carcinoid tumor into nude mice is reported. CSH, a voluminous hepatic metastasis of a primary bronchial carcinoid tumor (CSB) was resected and transplanted into three irradiated nude (Swiss-nu/nu) mice both by subcutaneous (SC) and intramuscular (IM) routes; the success rate was five of six. Heterotransplanted tumors took 4 to 5 months to appear in the mice and 1 month to attain a width of 0.5 cm. Both human and mouse tumors (named CSH-SC and CSH-IM) were studied by light and electron microscopy. They were Grimelius-positive, neuron-specific enolase-positive, and bombesin-negative by immunocytochemistry. Furthermore, CSH-SC cells presented characteristic (pear-shaped, rod-shaped, or tadpole-shaped) neurosecretory granules. Although CSB and CSH were slightly serotonin positive by immunocytochemistry, only a few serotonin-positive cells were found in CSH-SC and none in CSH-IM, suggesting partial loss of differentiation or an increase in serotonin catabolism during transplantation.
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
February 1995,
Endocrine journal,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
December 1978,
National Cancer Institute monograph,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
September 1979,
World journal of surgery,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
January 1988,
In vivo (Athens, Greece),
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
December 1983,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
January 1983,
Acta oto-laryngologica,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
December 1975,
The Keio journal of medicine,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
November 1978,
Cancer,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
September 1985,
Journal of neuropathology and experimental neurology,
Y J Ganem, and
J M Launay, and
M C Debons-Guillemin, and
J Lasneret, and
A M Roucayrol, and
J Lesser, and
G Peries, and
C Dreux
October 1975,
Gan,
