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More than 200 human cancers have been successfully transplanted into nude athymic mice in our laboratory. Strict sterile techniques must be applied in caring for these animals and meticulous attention given to the preparation of the surgical specimens. That the tumors remain human in the mice has been documented by isozyme and karyotype analyses. Also, histopathologic comparisons between the original human tumors and their transplanted counterparts in the mice are strikingly similar or identical. Preliminary results of chemotherapy of human cancers in the nude mice are extremely encouraging. At this point, we believe that the greatest potential for the nude mice lies in their use in testing anticancer therapies for human neoplasms without placing the patients at risk.
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
January 1981,
Investigative urology,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
February 1995,
Endocrine journal,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
December 1978,
National Cancer Institute monograph,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
September 1979,
World journal of surgery,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
October 1975,
Gan,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
August 1991,
Cancer,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
January 1988,
In vivo (Athens, Greece),
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
June 1979,
The Bulletin of Tokyo Medical and Dental University,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
January 1983,
Acta oto-laryngologica,
B C Giovanella, and
J S Stehlin, and
L J Williams, and
S S Lee, and
R C Shepard
December 1975,
The Keio journal of medicine,
