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The toxic effects of 4-tert-octylphenol on the reproductive system of male rats. 2006

Qian Bian, and Jie Qian, and Lichun Xu, and Jianfeng Chen, and Ling Song, and Xinru Wang
The Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.

The aim of the present study is to investigate the toxic effect of 4-tert-octylphenol (OP) on testicular functions of rats. Male Sprague-Dawley rats were orally administered different doses of OP at the levels of 0 (control), 50, 150 and 450 mg/kg/d for 30 d. Testicular functions were assessed by histopathology, testicular sperm head counts, daily sperm production, sperm motility (measured by computer assisted sperm analysis, CASA) and biochemical indices (marker testicular enzymes). The size and weight of the testis, epididymis, and prostate were reduced in all the three dosages. Histopathologically, damages of spermatogenic cells and Sertoli cells were observed by electron microscope. Testicular sperm numbers, daily sperm production and activity of alkaline phosphatase (ALP) were decreased significantly in the 450 mg/kg/d OP group. The motility of spermatozoa was reduced significantly in 150 and 450 mg/kg/d treated groups. These data demonstrate that OP affects testicular functions. The primary sites of action may be spermatogenic cells and Sertoli cells. The results of the present study provide first information of OP on sperm motility.

UI MeSH Term Description Entries
D008297 Male Males
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010636 Phenols Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D011467 Prostate A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM. Prostates
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D004822 Epididymis The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
D004968 Estrogens, Non-Steroidal Non-steroidal compounds with estrogenic activity. Estrogens, Nonsteroidal,Estrogens, Non Steroidal,Non-Steroidal Estrogens,Nonsteroidal Estrogens
D006651 Histocytochemistry Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods. Cytochemistry
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013076 Sperm Count A count of SPERM in the ejaculum, expressed as number per milliliter. Sperm Number,Count, Sperm,Counts, Sperm,Number, Sperm,Numbers, Sperm,Sperm Counts,Sperm Numbers

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