BIOMAT Database Logo BIOMAT Database Logo

Effect of chemotherapy on circulating steroid hormone levels in postoperative premenopausal breast cancer patients. 1991

S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Department of Biological Sciences, Quaid-i-Azam University, Islamabad.

Serum levels of 17-beta oestradiol, testosterone and progesterone were determined in postoperative premenopausal breast cancer patients. In patients receiving chemotherapy circulating 17-beta oestradiol values decreased significantly compared to control group during the sampling/drug regimens employed. Among the control group, however, the oestradiol levels remained high throughout the sampling period. Testosterone levels in patients were also significantly low compared to control group throughout the sampling regimen up to 28 days. In contrast the levels of progesterone in patients were elevated and remained high compared to the corresponding controls. A positive correlation was found between the drop in serum oestradiol and testosterone levels following the initiation of chemotherapy and the regression of the tumour size. Steroid hormone levels in the serum of breast cancer patients receiving chemotherapy can serve as clinical tools to monitor the progress of the disease and response to therapy.

UI MeSH Term Description Entries
D011184 Postoperative Period The period following a surgical operation. Period, Postoperative,Periods, Postoperative,Postoperative Periods
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002285 Carcinoma, Intraductal, Noninfiltrating A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma. Carcinoma, Intraductal,DCIS,Ductal Carcinoma In Situ,Atypical Ductal Hyperplasia,Intraductal Carcinoma, Noninfiltrating,Atypical Ductal Hyperplasias,Carcinoma, Noninfiltrating Intraductal,Carcinomas, Intraductal,Carcinomas, Noninfiltrating Intraductal,Ductal Hyperplasia, Atypical,Ductal Hyperplasias, Atypical,Hyperplasia, Atypical Ductal,Hyperplasias, Atypical Ductal,Intraductal Carcinoma,Intraductal Carcinomas,Intraductal Carcinomas, Noninfiltrating,Noninfiltrating Intraductal Carcinoma,Noninfiltrating Intraductal Carcinomas
D003131 Combined Modality Therapy The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012739 Gonadal Steroid Hormones Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE. Gonadal Steroid Hormone,Sex Hormone,Sex Steroid Hormone,Sex Steroid Hormones,Sex Hormones,Hormone, Gonadal Steroid,Hormone, Sex,Hormone, Sex Steroid,Hormones, Gonadal Steroid,Hormones, Sex Steroid,Steroid Hormone, Gonadal,Steroid Hormone, Sex,Steroid Hormones, Gonadal,Steroid Hormones, Sex

Related Publications

S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Effect of chemotherapy with or without buserelin on serum hormone levels in premenopausal women with breast cancer.
January 1991, European journal of cancer (Oxford, England : 1990),
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Tidal chemotherapy in premenopausal patients with hormone receptor positive breast cancer.
May 2017, Medical hypotheses,
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Chemotherapy in Premenopausal Breast Cancer Patients.
October 2015, Breast care (Basel, Switzerland),
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue.
September 2018, Turkish journal of surgery,
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Circulating steroid hormone levels and risk of breast cancer for postmenopausal women.
February 2010, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Effect of adjuvant chemotherapy on the circulating levels of pituitary hormones in postmenopausal breast cancer patients.
September 1995, Annals of Saudi medicine,
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Effect of chemotherapy on circulating gastrointestinal hormone levels in ovarian cancer patients: relationship to nausea and vomiting.
June 2005, Scandinavian journal of gastroenterology,
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
[Effects of chemotherapy on circulating angiogenic factor levels in patients with breast cancer].
March 2007, Zhonghua zhong liu za zhi [Chinese journal of oncology],
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women.
October 2006, Journal of the National Cancer Institute,
S Anjum, and S Khan, and S M Baig, and A Khanum, and M Z Haider, and M H Qazi
Changes in serum hydroxyvitamin D levels of breast cancer patients during tamoxifen treatment or chemotherapy in premenopausal breast cancer patients.
May 2014, European journal of cancer (Oxford, England : 1990),
Copied contents to your clipboard!