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Huntington's disease (HD) is tightly linked to genetic markers in 4p16.3. We have used a regional somatic cell hybrid mapping panel to isolate and map 25 cosmids to the proximal portion of 4p16.3 and 17 cosmids to the distal portion. The latter were positioned by long-range restriction mapping relative to previously mapped markers. One cosmid, L6 (D4S166), spans the critical breakpoint in the mapping panel that distinguishes proximal and distal 4p16.3. Four of the cosmids mapped distal to D4S90, the previous terminal marker on 4p, and stretched to within 75 kb of the telomere. Several of the cosmids that mapped between L6 and D4S90 were clustered near a number of previously isolated clones in a region with many NotI sites. Cosmid E4 (D4S168) was localized immediately proximal to the one remaining gap in the long-range restriction map of distal 4p16.3. Although pulsed field gel mapping with E4 failed to link the two segments of the map, the intervening gap was excluded as a potential site for the HD gene by genetic analysis.
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
April 1996,
Genome research,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
January 1995,
Muscle & nerve. Supplement,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
January 1995,
Muscle & nerve. Supplement,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
July 1993,
Human molecular genetics,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
January 1990,
Science (New York, N.Y.),
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
February 1994,
Genomics,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
May 1997,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
May 1992,
Genomics,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
April 1993,
Genomics,
W L Whaley, and
G P Bates, and
A Novelletto, and
Z Sedlacek, and
S Cheng, and
D Romano, and
E Ormondroyd, and
B Allitto, and
C Lin, and
S Youngman
December 1992,
The Japanese journal of human genetics,
