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Synthesis, stereochemistry, and biological properties of the depigmenting agents, melanostatin, feldamycin and analogs. 1991
K Imae, and
H Kamachi, and
H Yamashita, and
T Okita, and
S Okuyama, and
T Tsuno, and
T Yamasaki, and
Y Sawada, and
M Ohbayashi, and
T Naito
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Syntheses of melanostatin and feldamycin have been completed from L-serine and L-threonine, respectively, and the configuration of unknown asymmetric carbons determined. Feldamycin analogs have also been prepared and the L-tryptophyl analog was the most potent in the depigmentation of Streptomyces bikiniensis and B16 melanoma cells.
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December 1990,
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Journal of medicinal chemistry,
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T Okita, and
S Okuyama, and
T Tsuno, and
T Yamasaki, and
Y Sawada, and
M Ohbayashi, and
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November 1974,
Journal of medicinal chemistry,
K Imae, and
H Kamachi, and
H Yamashita, and
T Okita, and
S Okuyama, and
T Tsuno, and
T Yamasaki, and
Y Sawada, and
M Ohbayashi, and
T Naito
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Voprosy onkologii,
K Imae, and
H Kamachi, and
H Yamashita, and
T Okita, and
S Okuyama, and
T Tsuno, and
T Yamasaki, and
Y Sawada, and
M Ohbayashi, and
T Naito
October 1978,
Archives of dermatology,
K Imae, and
H Kamachi, and
H Yamashita, and
T Okita, and
S Okuyama, and
T Tsuno, and
T Yamasaki, and
Y Sawada, and
M Ohbayashi, and
T Naito
December 1975,
Journal of pharmaceutical sciences,
K Imae, and
H Kamachi, and
H Yamashita, and
T Okita, and
S Okuyama, and
T Tsuno, and
T Yamasaki, and
Y Sawada, and
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October 2016,
Chemical biology & drug design,
