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On the basis of the two-dimensional 1H NMR studies the conformation of melanocyte inhibiting hormone (HCl.Pro-Leu-Gly-NH2, MIF) and its five analogues with p-substituted phenylalanine has been determined. Structure-antidepressant activity relationship (examined by the Porsolt test) of MIF and its analogues has been estimated by means of the multivariate statistical analysis, the vicinal spin coupling constants, which determine phi and chi dihedral angles of the second amino acid and phi and dihedral angle of glycine, being selected as structural parameters. It is shown that a biologically active conformation (10-membered beta-turn II) is realized for the considered peptides.
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
February 1982,
International journal of peptide and protein research,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
June 2005,
Chemistry & biology,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
January 1990,
Annals of the New York Academy of Sciences,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
March 1994,
Biochemistry,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
April 1969,
Psychopharmacology bulletin,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
January 1977,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
January 1991,
The Journal of antibiotics,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
February 1999,
The journal of peptide research : official journal of the American Peptide Society,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
December 2008,
Neuropharmacology,
Iu E Shapiro, and
V Ia Gorbatiuk, and
V M Kabanov, and
A A Mazurov, and
S A Andronati, and
B A Lobasiuk, and
N Ia Golovenko, and
M G Rokachinskaia
July 1997,
Nature biotechnology,
