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Artificial hyperprolactinemia was produced by intravenous administration of synthetic TRH to ovariectomized sows. The prolactin response varied markedly between individual animals. In the range of 25 to 400 mug TRH, the prolactin response was not related to the intravenous dose of TRH. Repetitive administration of 50 mug TRH over a 24-hour period resulted in a prolactin secretory pattern which decreased over time. Prolactin responses to intramuscular doses of TRH were less than those observed after intravenous administration.
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