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The effects of thyrotropin-releasing hormone (TRH) and the TRH-analogs, 4-fluoro-Im-TRH (4-F-TRH) and 2-trifluoromethyl-Im-TRH (2-TFM-TRH), on the cardiovascular system and prolactin (PRL) release were examined in conscious rats. TRH (2.8 or 28 nmol) injected into the anterior hypothalamus produced dose-dependent increments in blood pressure and heart rate; plasma PRL was increased twofold after the higher dose of TRH. 4-F-TRH had effects similar to those of TRH on both the cardiovascular and PRL response. In contrast, the 2-TFM-TRH was significantly less active than TRH or 4-F-TRH in eliciting tachycardia, yet was noticeably more potent in affecting PRL release. These data suggest that the receptors for TRH-induced PRL release may be different from TRH-receptors which mediate central cardiovascular responses.
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
September 1982,
Theriogenology,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
February 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
January 1986,
Life sciences,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
January 1977,
The Journal of clinical endocrinology and metabolism,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
August 1977,
The Journal of clinical endocrinology and metabolism,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
October 1975,
Acta endocrinologica,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
September 1987,
Life sciences,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
December 1974,
The Journal of clinical endocrinology and metabolism,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
November 1974,
Endocrinology,
G Feuerstein, and
D Lozovsky, and
L A Cohen, and
V M Labroo, and
K L Kirk, and
I J Kopin, and
A I Faden
April 1987,
Acta endocrinologica,
