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The antihypertensive and renal haemodynamic effects of 5 mg/day tertatolol (T), a new nonselective and long-acting beta-adrenoceptor blocker, and 80 mg/day nadolol (N) in hypertensive patients with mild renal impairment have been compared in a randomized double-blind trial. Before and after 30 days of active treatment glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were determined by use of a simultaneous i.v. bolus of 99mTc-DTPA and 131I-hippuran. Both T and N significantly decreased blood pressure and heart rate, and induced an insignificant increase in GFR and ERPF. There were no differences between the effect of the treatments on blood pressure and heart rate. Despite the persistent fall in BP and HR, renal function was maintained during both T or N treatment, suggesting that both drugs may act by a direct intrarenal vasodilator mechanism.
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
January 1991,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
October 1983,
British journal of clinical pharmacology,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
January 1986,
American journal of nephrology,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
January 1986,
American journal of nephrology,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
July 1988,
American journal of hypertension,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
January 1993,
Pharmacotherapy,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
January 1979,
British journal of clinical pharmacology,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
October 1985,
British journal of clinical pharmacology,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
December 1985,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
F Fallo, and
M Gregianin, and
F Bui, and
C Macrì, and
P Folino, and
F Mantero
November 1989,
American journal of hypertension,
