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Effects of oral administration of equipotent antihypertensive doses of propranolol and nadolol on renal function were examined in 20 hypertensive patients with moderately impaired renal function. Creatinine clearance increased, and serum beta 2-microglobulin concentrations decreased, when patients were switched from propranolol to nadolol therapy (creatinine clearance = 46.7 +/- 4.9 ml min-1 on propranolol and 52.7 +/- 5.9 on nadolol; beta 2-microglobulin = 6.14 +/- 0.66 mg l-1 on propranolol and 5.62 +/- 0.62 on nadolol). When patients were put back on propranolol, their creatinine clearances (45.9 +/- 5.0 ml min-1) and serum beta 2-microglobulin concentrations (6.51 +/- 0.67 mg l-1) returned to values comparable to those obtained before the change to nadolol was made. Serum beta 2-microglobulin concentrations correlated significantly with creatinine clearance (r = -0.819, P less than 0.001).
K K Pun, and
C K Yeung, and
M K Chan
January 1994,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
K K Pun, and
C K Yeung, and
M K Chan
October 1986,
British journal of clinical pharmacology,
K K Pun, and
C K Yeung, and
M K Chan
May 1996,
Anesthesia and analgesia,
K K Pun, and
C K Yeung, and
M K Chan
January 1973,
Praxis der Pneumologie,
K K Pun, and
C K Yeung, and
M K Chan
March 1987,
Clinical pharmacology and therapeutics,
K K Pun, and
C K Yeung, and
M K Chan
October 1983,
British journal of clinical pharmacology,
K K Pun, and
C K Yeung, and
M K Chan
January 1992,
Therapia Hungarica (English edition),
K K Pun, and
C K Yeung, and
M K Chan
October 1990,
Journal of cardiovascular pharmacology,
K K Pun, and
C K Yeung, and
M K Chan
January 1984,
Gastroenterology,
K K Pun, and
C K Yeung, and
M K Chan
January 1991,
European journal of clinical pharmacology,
