Autologous peripheral blood stem cell transplantation in malignancies involving bone marrow. 1991

S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
Istituto di Semeiotica Medica, Facoltà di Medicina e Chirurgia, Università Cattolica del Sacro Cuore, Rome, Italy.

Six patients suffering from refractory malignancies (3 NHL, 1 MM, 1 AML, 1 neuroblastoma) received high dose of chemotherapy and autologous peripheral blood stem cell transplantation (APBSCT). The recruitment of PBSC was performed using conventional salvatage schedules of therapy. The patients received a median of 8.69 MNC/kg bw and 20.87 CFU-GM x 10(4)/kg bw. Prompt engraftment occurred in all patients and the median number of days to achieve WBC greater than 1 x 10(9)/l was 16.5 (range 7-26), PMN greater than 0.5 x 10(9)/l was 21.5 (range 6-37) and PLTs greater than 50 x 10(9)/l was 17.5 (range 4-31). Four patients achieved a complete remission. One patient (neuroblastoma) died of progressive disease after a partial response. One patient died in relapse because of drug related toxicity.

UI MeSH Term Description Entries
D007558 Italy A country in southern Europe, a peninsula extending into the central Mediterranean Sea, northeast of Tunisia. The capital is Rome. Sardinia
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D010198 Pancytopenia Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets. Pancytopenias
D012074 Remission Induction Therapeutic act or process that initiates a response to a complete or partial remission level. Induction of Remission,Induction, Remission,Inductions, Remission,Remission Inductions
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D003131 Combined Modality Therapy The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D005069 Evaluation Studies as Topic Works about studies that determine the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. Critique,Evaluation Indexes,Evaluation Methodology,Evaluation Report,Evaluation Research,Methodology, Evaluation,Pre-Post Tests,Qualitative Evaluation,Quantitative Evaluation,Theoretical Effectiveness,Use-Effectiveness,Critiques,Effectiveness, Theoretical,Evaluation Methodologies,Evaluation Reports,Evaluation, Qualitative,Evaluation, Quantitative,Evaluations, Qualitative,Evaluations, Quantitative,Indexes, Evaluation,Methodologies, Evaluation,Pre Post Tests,Pre-Post Test,Qualitative Evaluations,Quantitative Evaluations,Report, Evaluation,Reports, Evaluation,Research, Evaluation,Test, Pre-Post,Tests, Pre-Post,Use Effectiveness
D005260 Female Females

Related Publications

S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
December 1995, Medical oncology (Northwood, London, England),
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
July 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
January 1993, Lancet (London, England),
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
November 1993, Bone marrow transplantation,
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
January 1996, Cancer investigation,
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
January 1992, Bone marrow transplantation,
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
February 2009, Zhongguo shi yan xue ye xue za zhi,
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
March 1997, American journal of hematology,
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
February 1992, Cancer,
S Sica, and G Leone, and L Teofili, and L Pierelli, and G Menichella, and A Di Mario, and A Paoloni, and M S Iovino, and B Bizzi
March 1994, Archives of disease in childhood,
Copied contents to your clipboard!