-transparent.png){kind=logo}
Peripheral blood stem cells (PBSC) were used to augment autologous bone marrow transplantation (ABMT), aiming to hasten engraftment after high dose treatment in a group of heavily pretreated patients. PBSC were obtained by leukapheresis during the rebound after standard chemotherapy. In 11 patients aged 7-17 years, high dose chemotherapy consisted of busulphan 16 mg/kg orally with melphalan 160 mg/m2 intravenously for seven patients, and melphalan 200 mg/m2 intravenously alone for four. The median number of granulocyte-macrophage colony forming units in the reinfused PBSC was 3.42 x 10(4)/kg (3.03-18.01) and bone marrow 12.4 x 10(4)/kg (4.16-28.6). Neutrophil recovery to > or = 0.5 x 10(9)/l and platelet transfusion independence occurred at a median of 14 days (11-18) and 22 days (9-84) respectively. In five patients the early engraftment was transient with neutrophils again dropping below 0.5 x 10(9)/l then slowly recovering. There was one toxic death due to sepsis. PBSC harvesting in these children was undertaken without interrupting routine chemotherapy and without the use of bone marrow growth factors. In some patients PBSC failed to influence engraftment and the use of combined chemotherapy and growth factor priming for PBSC collection may give improved results.
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
January 1993,
Lancet (London, England),
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
January 1990,
Haematologica,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
November 1993,
Bone marrow transplantation,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
March 1991,
Haematologica,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
January 1999,
Bailliere's best practice & research. Clinical haematology,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
September 1995,
Ugeskrift for laeger,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
February 2009,
Zhongguo shi yan xue ye xue za zhi,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
January 1996,
Cancer investigation,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
January 1995,
Acta haematologica Polonica,
P L Mitchell, and
V B Shepherd, and
H M Proctor, and
M Dainton, and
S D Cabral, and
C R Pinkerton
January 1992,
Bone marrow transplantation,
